Background: Stress – related disturbances are classified among the health problems that have global interest, especially which are related to gastrointestinal system. The oxidative stress is confirmed to be responsible for the development of gastrointestinal mucosa ulcers and necrosis. That is accompanied with the release of inflammatory mediators and many other factors. Vitamin E is a fat-soluble, free radicals scavenger antioxidant. It has anti-inflammatory and membrane-stabilizing properties. Objective: The present study highlights the evaluation of vitamin E efficiency in the treatment of stress-induced gastric ulcers in rats. Materials and methods: stomach injury was induced in fasted rats by cold- restraint stress method. Vitamin E was administered orally at a dose of 100 mg/kg for 7 consecutive days. Rats were sacrificed on the 8th day. Assessment of the stomach injury was observed by body weight changes, macroscopic examination of stomach samples, and biochemical measurement of lipid peroxides and SOD enzyme activity. Results: vitamin E administration reduced the stomach injury degree, and rats body weight with statistical significance compared to CRS group (p<0.05). The treatment significantly increased SOD activity (p<0.05). As well as, it decreased lipid peroxides levels. Conclusion: Vitamin E exerted good effects in healing of stressinduced gastric ulcers in rats