A laboratory experiment was carried out to study the interaction of the cyst nematode Heterodera  latipons and the root rot fungus, Cochliobolus sativus,on Wheat  cv. Sham3. Six treatments were examined to determine their effects on the growth and productivity of the wheat cultivar, and on the infectivity of the root rot fungus and cyst nematode. These treatments were: non-inoculated check, nematode inoculation, fungus inoculation, nematode plus fungus inoculation at planting, fungus then nematode inoculation one month later, and nematode followed by fungus inoculation one month later. Results showed that each of the nematode and the fungus inoculations as well as nematode followed by fungus inoculation one month later have greatly suppressed (P≤ 0.05) total plant weight, root weight and number of spikes/plant. However, weight of 1000 wheat kernels was greatly suppressed (P≤0.05) by the treatments where nematode alone, nematode plus fungus at planting, and nematode then fungus one month later were applied. Nematode reproduction reached its maximum in the treatment of nematode alone inoculation, and gradually decreased by the treatments of the nematode plus fungus combinations until it reached its lowest value in the treatment where plants were inoculated with nematodes followed by fungus one month later. On the other hand, percentage of C. sativus root rot infection was only suppressed (P≤0.05)in the treatment where plants were inoculated with the fungus followed by nematode one month later