It is noteworthy to examine the efficacies of vitamin E and its combination with an antagonist of histamine receptor 2 in the treatment of stress gastric ulcers. Animals were divided into 6 groups; group 1 (normal control), group 2 (Cold – restraint stress; CRS), group 3 (ranitidine 20 mg/kg), group 4 (vitamin E 100 mg/kg), group 5 (ranitidine 10 mg/kg + vitamin E 50 mg/kg ), group 6 (ranitidine 5 mg/kg + vitamin E 50 mg/kg ). Drugs were administered orally for 7 consecutive days 1 hour after induction of the gastric injury. Rats were sacrificed. The assessment of stomach damage was by body weight observation, macroscopic examinations, histological study, and determination of oxidative stress markers (MDA stomach content and SOD enzyme activity). Present findings showed that the using of vitamin E with ranitidine is dose-dependent, and more effective than using vitamin E alone in the management of stress-induced lesions. Vitamin E caused a remarkable body weight decrease.